Synergistic Roles of Amelogenin and Ameloblastin
نویسندگان
چکیده
منابع مشابه
Tracking Endogenous Amelogenin and Ameloblastin In Vivo
Research on enamel matrix proteins (EMPs) is centered on understanding their role in enamel biomineralization and their bioactivity for tissue engineering. While therapeutic application of EMPs has been widely documented, their expression and biological function in non-enamel tissues is unclear. Our first aim was to screen for amelogenin (AMELX) and ameloblastin (AMBN) gene expression in mandib...
متن کاملAnalysis of co-assembly and co-localization of ameloblastin and amelogenin
Epithelially-derived ameloblasts secrete extracellular matrix proteins including amelogenin, enamelin, and ameloblastin. Complex intermolecular interactions among these proteins are believed to be important in controlling enamel formation. Here we provide in vitro and in vivo evidence of co-assembly and co-localization of ameloblastin with amelogenin using both biophysical and immunohistochemic...
متن کاملAmeloblastin peptide encoded by exon 5 interacts with amelogenin N-terminus
Interactions between enamel matrix proteins are important for enamel biomineralization. In recent in situ studies, we showed that the N-terminal proteolytic product of ameloblastin co-localized with amelogenin around the prism boundaries. However, the molecular mechanisms of such interactions are still unclear. Here, in order to determine the interacting domains between amelogenin and ameloblas...
متن کاملAmeloblastin
elomeric proteins may have an unexpected connection to the mitotic spindle. On page 819, Xu and Blackburn provide evidence that the human homologue of a yeast telomere-binding protein is found on anaphase midzone microtubules. The telomeric functions of the human and yeast versions of this protein, Rif1, have diverged during evolution. In budding yeast, Rif1 is a telomere-bound negative regulat...
متن کاملCloning, characterization and immunolocalization of human ameloblastin.
Amelogenesis imperfecta is a broad classification of hereditary enamel defects, exhibiting both genetic and clinical diversity. Most amelogenesis imperfecta cases are autosomal dominant disorders, yet only the local hypoplastic form has been mapped to human chromosome 4q between D4S242 1 and the albumin gene. An enamel protein cDNA, termed ameloblastin (also known as amelin and sheathlin), has ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2009
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034509334749